Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(Triisopropylsilyl)-1H-Pyrrole is a high-value, organoboron building block featuring a protected pyrrole core, essential for modern synthetic chemistry. Its primary value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel heterocyclic compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates containing pyrrole or indole motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as conductive polymers and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Specifically designed as a boronic ester partner in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the pyrrole unit into molecular scaffolds.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for biological target identification and mechanism studies.
• Academic & Industrial R&D: A versatile reagent for methodology development and the construction of complex, polyfunctional molecules in laboratory-scale and pilot-scale syntheses.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(Triisopropylsilyl)-1H-Pyrrole
CAS No.	365564-11-0
Molecular Formula	C20H38BNO2Si
Molecular Weight	363.42 g/mol
Synonyms	1-(Triisopropylsilyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole; 1H-Pyrrole, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(1,1-dimethylethyl)dimethylsilyl]-; TIPS-Protected Pyrrole-3-Boronic Acid Pinacol Ester; 3-Borono-1-(triisopropylsilyl)-1H-pyrrole pinacol ester; N-TIPS-Pyrrole-3-boronic acid pinacol ester; 1-Triisopropylsilyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrole
EINECS	Contact for details

Quality Control

Our production of 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(Triisopropylsilyl)-1H-Pyrrole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ¹¹B) and HPLC analysis, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.