Description

4-([4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thien-2-Yl]Methyl)Morpholine is a high-value, synthetically versatile boronic ester derivative that serves as a critical building block in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries seeking to construct complex heterocyclic architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing thiophene and morpholine pharmacophores for therapeutic areas like oncology and CNS disorders.
• Suzuki-Miyaura Cross-Coupling: A pivotal reagent for palladium-catalyzed cross-coupling reactions to create biaryl and heteroaryl structures central to drug discovery pipelines.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science & OLED Development: Building block for creating conjugated polymers and small molecule emitters used in organic light-emitting diodes (OLEDs) and electronic materials.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Scale-Up Process Chemistry: Suitable for use in process optimization and pilot-scale synthesis due to its stability relative to boronic acids.

Basic Information

Product Name	4-([4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thien-2-Yl]Methyl)Morpholine
CAS No.	364794-85-4
Molecular Formula	C15H24BNO3S
Molecular Weight	309.23 g/mol
Synonyms	2-(4-Morpholinomethylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine; 2-[4-(Morpholin-4-ylmethyl)thiophen-2-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-((5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-3-yl)methyl)morpholine (isomer); Morpholine, 4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]methyl]-; Pinacol [4-(morpholinomethyl)thiophen-2-yl]boronate
EINECS	Contact for details

Quality Control

Every batch of our 4-([4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thien-2-Yl]Methyl)Morpholine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions and regulatory starting material submissions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.