Description

4,4,5,5-Tetramethyl-2-(3-Nitro-4-Phenoxyphenyl)-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile intermediate for the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for forming carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable synthetic pathways. The product is supplied with a CAS number of 364354-15-4.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for complex molecules containing biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aromatic couplings.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for imaging and diagnostic applications.
• Academic & Industrial R&D: A fundamental reagent for method development and library synthesis in medicinal chemistry and process chemistry.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(3-Nitro-4-Phenoxyphenyl)-1,3,2-Dioxaborolane
CAS No.	364354-15-4
Molecular Formula	C18H20BNO5
Molecular Weight	341.17 g/mol
Synonyms	2-(3-Nitro-4-phenoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Nitro-4-phenoxyphenylboronic acid pinacol ester; (3-Nitro-4-phenoxyphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[3-nitro-4-(phenoxy)phenyl]-1,3,2-dioxaborolane; PINACOL (3-NITRO-4-PHENOXYPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(3-Nitro-4-Phenoxyphenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with lot-specific data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.