Description

1(2H)-Naphthalenone, 3,4,5,6,7,8-Hexahydro-5,6-Dihydroxy-6-Methyl-4-(1-Methylethyl)-, (4S,5S,6R)- is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. This compound is valued for its complex, functionalized decalin core structure, which serves as a versatile chiral building block. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of complex drug candidates, particularly those with sterically demanding, polycyclic frameworks.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or intermediate in catalytic asymmetric reactions to construct molecules with high enantiomeric purity.
• Natural Product Synthesis: Serves as a core scaffold in the total synthesis of terpenoids and other natural products featuring hydronaphthalenone motifs.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, advanced materials, and ligands for catalysis where precise stereochemistry is critical.
• Academic & Industrial R&D: Used in research laboratories for method development and exploring new chemical spaces in medicinal and process chemistry.

Basic Information

Product Name	1(2H)-Naphthalenone, 3,4,5,6,7,8-Hexahydro-5,6-Dihydroxy-6-Methyl-4-(1-Methylethyl)-, (4S,5S,6R)-
CAS No.	363610-30-4
Molecular Formula	C14H22O3
Molecular Weight	238.33 g/mol
Synonyms	(4S,5S,6R)-5,6-Dihydroxy-6-methyl-4-(propan-2-yl)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one; (4S,5S,6R)-3,4,5,6,7,8-Hexahydro-5,6-dihydroxy-6-methyl-4-(1-methylethyl)-1(2H)-naphthalenone; 5,6-Dihydroxy-6-methyl-4-isopropyl-3,4,5,6,7,8-hexahydro-1(2H)-naphthalenone (stereoisomer); Chiral Hexahydronaphthalenone Diol; Stereoisomeric Dihydroxy Isopropyl Tetralone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, and chiral analysis. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.