Description

(4-Benzyloxycarbonylaminophenyl)Boronic Acid, Pinacol Ester is a protected boronic acid derivative, a crucial intermediate in modern synthetic organic chemistry. Its primary value lies in its enhanced stability compared to the free boronic acid, making it a superior reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to construct complex biaryl and heterobiaryl scaffolds for active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those containing biphenyl or aryl-heteroaryl motifs.
• Suzuki-Miyaura Cross-Coupling: A stable, air-handleable reagent for palladium-catalyzed carbon-carbon bond formation, enabling the construction of complex molecular architectures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific aryl coupling steps.
• Material Science: Intermediate for the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Potential use in the development of enzyme inhibitors or as a handle for bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for bespoke synthesis projects requiring high-purity boronic ester intermediates.

Basic Information

Product Name	(4-Benzyloxycarbonylaminophenyl)Boronic Acid, Pinacol Ester
CAS No.	363186-06-5
Molecular Formula	C21H26BNO4
Molecular Weight	367.25 g/mol
Synonyms	4-[(Benzyloxy)carbonylamino]benzeneboronic acid pinacol ester; N-Cbz-4-aminophenylboronic acid pinacol ester; [4-[[(Benzyloxy)carbonyl]amino]phenyl]boronic acid pinacol ester; (4-((Benzyloxycarbonyl)amino)phenyl)boronic acid pinacol ester; Pinacol [4-[[(benzyloxy)carbonyl]amino]phenyl]boronate; N-Carbobenzoxy-4-aminophenylboronic acid pinacol ester; B-[4-[[(Phenylmethoxy)carbonyl]amino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our (4-Benzyloxycarbonylaminophenyl)Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccator to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.