Description

Benzoic Acid, 2-Amino-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is a high-value, multifunctional chemical building block that combines a benzoic acid ester core with a reactive amino group and a pinacol boronate ester moiety. This compound matters for its versatility as a key intermediate in modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling, which is fundamental to pharmaceutical and advanced materials research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing biaryl or heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require boronic ester coupling steps.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl or vinyl halides, a cornerstone of C-C bond formation.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and bioconjugates for diagnostic and research applications.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	Benzoic Acid, 2-Amino-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester
CAS No.	363185-87-9
Molecular Formula	C15H22BNO4
Molecular Weight	291.15 g/mol
Synonyms	Methyl 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid Methyl Ester; 5-Borono-2-aminobenzoic Acid Methyl Ester Pinacol Ester; Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)anthranilate; 2-Amino-5-Bpin-benzoic Acid Methyl Ester; CAS 363185-87-9
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 2-Amino-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation, especially after opening the original packaging. Ideal storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.