Description

Tiprolisant Oxalate is a high-purity, small molecule compound of significant interest in advanced pharmaceutical research and development. Its primary value lies in its role as a potent and selective histamine H3 receptor antagonist, making it a critical intermediate for investigating novel therapeutic pathways. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on central nervous system (CNS) disorders, cognitive enhancement, and metabolic research. We supply this material globally with a commitment to stringent quality control and reliable supply chain integrity.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced drug candidates targeting the histamine H3 receptor.
• Neurological Research: Used in preclinical studies for conditions such as narcolepsy, attention deficit hyperactivity disorder (ADHD), and obesity, where H3 receptor modulation is relevant.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation of related pharmaceutical products.
• Biochemical Assay Development: Utilized in vitro to study receptor binding affinity, selectivity, and functional activity in high-throughput screening (HTS) campaigns.
• Academic Research: Supports basic scientific research in universities and institutes exploring the role of the histamine system in physiology and disease.
• Process Chemistry & Scale-Up: Provides a defined starting material for process optimization and pilot-scale synthesis under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Tiprolisant Oxalate
CAS No.	362665-57-4
Molecular Formula	C17H26N4O • C2H2O4
Molecular Weight	406.46 g/mol
Synonyms	Tiprolisant hydrogen oxalate; 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]piperidine oxalate; BF2.649 oxalate; Cipralisant oxalate; (R)-3-(4-Chlorophenyl)-N-methyl-3-(piperidin-1-yl)propan-1-amine oxalate; Histamine H3 receptor antagonist BF2.649; 1-[3-[3-(p-Chlorophenyl)propoxy]propyl]piperidine oxalate
EINECS	Contact for details

Quality Control

Our Tiprolisant Oxalate is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We can supply material suitable for research use and development under quality standards appropriate for advanced pharmaceutical applications. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.