Description

4-Hydroxy-3-(p-Diazophenylphosphorylcholine) Phenylacetic Acid is a specialized diazonium salt derivative with a phosphorylcholine moiety, designed for advanced bioconjugation and surface modification applications. This compound matters for its unique ability to act as a photoactivatable crosslinker, enabling the covalent attachment of biomolecules under mild, controlled conditions. It is primarily needed by researchers and manufacturers in the pharmaceutical, diagnostics, and biomaterials sectors for developing targeted drug delivery systems, biosensors, and functionalized medical devices.

Application

• Bioconjugation Reagent: For the covalent immobilization of proteins, antibodies, or peptides onto surfaces or other molecules via light-induced coupling.
• Biomaterial Functionalization: Surface modification of polymers, hydrogels, and nanoparticles to introduce bioactive phosphorylcholine groups, enhancing biocompatibility and reducing non-specific binding.
• Diagnostic Assay Development: Key component in the fabrication of advanced immunoassays and biosensor platforms requiring stable, oriented antibody attachment.
• Drug Delivery System Fabrication: Used to create targeted nanocarriers by linking therapeutic agents to targeting ligands through a photo-cleavable or stable linkage.
• Cell Biology Research: Tool for studying cell-surface interactions and membrane dynamics by labeling specific membrane components.
• Chromatography Media: Ligand for affinity chromatography columns designed to purify specific biomolecules.

Basic Information

Product Name	4-Hydroxy-3-(p-Diazophenylphosphorylcholine) Phenylacetic Acid
CAS No.	359435-74-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	p-Diazophenylphosphorylcholine Phenylacetic Acid Derivative; 4-Hydroxy-3-(4-diazoniophenylphosphorylcholine)phenylacetate; Photoactivatable Phosphorylcholine Crosslinker; Diazonium Phenylphosphorylcholine Reagent; Light-sensitive Bioconjugation Agent; Aryl Diazonium Salt with Phosphorylcholine; CAS 359435-74-8
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-(p-Diazophenylphosphorylcholine) Phenylacetic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This compound is light-sensitive (store away from light) and may be moisture-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. Store away from strong acids and bases.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.