Description

1-Pyrrolidineaceticacid,α-Ethylidene-2-Oxo-,(Alphaz)-(9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in complex therapeutic areas. Pharmaceutical R&D and fine chemical manufacturers need this material for developing next-generation drugs, where precise molecular architecture is paramount for efficacy and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially for targeted therapies.
• API Synthesis: Used in the complex multi-step synthesis of proprietary Active Pharmaceutical Ingredients requiring specific pyrrolidine-based frameworks.
• Medicinal Chemistry Research: A valuable scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot and commercial production scales.
• Bioconjugation & Prodrug Development: Potential utility in designing linker molecules or modifying drug properties for improved delivery and pharmacokinetics.

Basic Information

Product Name	1-Pyrrolidineaceticacid,α-Ethylidene-2-Oxo-,(Alphaz)-(9Ci)
CAS No.	358629-39-7
Molecular Formula	C8H11NO3
Molecular Weight	169.18 g/mol
Synonyms	(αZ)-α-Ethylidene-2-oxo-1-pyrrolidineacetic acid; (Alphaz)-α-Ethylidene-2-oxo-1-pyrrolidineacetic acid; 1-Pyrrolidineacetic acid, α-ethylidene-2-oxo-, (αZ)-; 358629-39-7; (Z)-α-Ethylidene-2-oxopyrrolidine-1-acetic acid; (Z)-2-(2-Oxo-1-pyrrolidinylidene)butanoic acid; (5Z)-5-Ethylidene-2-oxo-5,6-dihydro-2H-pyrrolizine-1-carboxylic acid (tautomeric form).
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidineaceticacid,α-Ethylidene-2-Oxo-,(Alphaz)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (by chiral HPLC)
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.