Description

5,5-Dimethyl-2-(Thiophen-2-Yl)-1,3,2-Dioxaborinane is a high-value organoboron reagent, specifically a cyclic boronic ester, that serves as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a stable, protected boronic acid equivalent for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiophene heterocycles.
• Agrochemical Synthesis: Used in the research and production of novel pesticides, herbicides, and fungicides that require specific aryl-thiophene motifs.
• Suzuki-Miyaura Cross-Coupling: Acts as a stable, air- and moisture-tolerant boronic ester reagent for palladium-catalyzed carbon-carbon bond formation.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors, OLEDs, and conductive polymers.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Item	Details
Product Name	5,5-Dimethyl-2-(Thiophen-2-Yl)-1,3,2-Dioxaborinane
CAS No.	355408-55-8
Molecular Formula	C9H13BO2S
Molecular Weight	196.07 g/mol
Synonyms	2-(Thiophen-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; 2-Thiopheneboronic acid, cyclic ester with neopentyl glycol; 5,5-Dimethyl-2-(2-thienyl)-1,3,2-dioxaborinane; Thiophene-2-boronic acid neopentyl glycol ester; Neopentyl glycol thiophene-2-boronate; (Thiophen-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 5,5-Dimethyl-2-(Thiophen-2-Yl)-1,3,2-Dioxaborinane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC analysis, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP and ISO standards for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.