Description

2,3,4,5,6-Pentafluorobenzylzinc Bromide is a highly reactive organozinc reagent, a crucial building block for introducing the pentafluorobenzyl group into complex molecular frameworks. Its value lies in enabling efficient carbon-carbon bond formation, particularly in the synthesis of fluorinated aromatic compounds which are pivotal in advanced material and pharmaceutical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries, where precise fluorination is required to modulate the properties of target molecules.

Application

• Key intermediate in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and agrochemicals.
• Used in Negishi cross-coupling reactions to create complex, multi-fluorinated biaryl structures.
• Building block for liquid crystal materials and organic semiconductors requiring specific fluorination patterns.
• Reagent for the preparation of PET (Positron Emission Tomography) tracer precursors utilizing fluorine-18 chemistry.
• Employed in academic and industrial R&D for exploring new fluorinated compounds with unique electronic properties.
• Facilitates the introduction of the pentafluorobenzyl group into ligands for catalysis and functional materials.

Basic Information

Product Name	2,3,4,5,6-Pentafluorobenzylzinc Bromide
CAS No.	352534-75-9
Molecular Formula	C7H2BrF5Zn
Molecular Weight	308.39 g/mol
Synonyms	(Pentafluorobenzyl)zinc bromide; Zinc, bromo(2,3,4,5,6-pentafluorophenyl)methyl-; Bromo(pentafluorobenzyl)zinc; Pentafluorobenzylzinc bromide solution; 2,3,4,5,6-Pentafluorobenzylzinc bromide solution; (Perfluorobenzyl)zinc bromide; C6F5CH2ZnBr
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorobenzylzinc Bromide is manufactured under stringent conditions to ensure batch-to-batch consistency and high reactivity. Quality is assured through comprehensive analytical techniques including NMR, titration, and GC/HPLC analysis. A Certificate of Analysis (COA) detailing purity, concentration (if in solution), and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its moisture-sensitive and easily oxidized nature, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions or as specified. Handle and store away from strong acids and oxidizing agents in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution (typically in THF)
Identification (NMR)	Conforms to structure
Assay (Titration)	≥ 0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (organics basis)
Water Content (Karl Fischer)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.