Description

tert-Butylzinc Bromide is an organozinc reagent, specifically a dialkylzinc compound, widely used as a versatile nucleophile in organic synthesis. Its value lies in its ability to efficiently transfer the tert-butyl group in cross-coupling and nucleophilic addition reactions, enabling the construction of complex molecular frameworks. This high-purity reagent is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it facilitates the synthesis of novel compounds and active ingredients.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing the tert-butyl moiety in the development of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and pesticides that require specific sterically hindered alkyl groups.
• Material Science Research: Employed in the preparation of organometallic precursors for catalysts and novel polymeric or electronic materials.
• Cross-Coupling Reactions: Acts as an efficient nucleophile in Negishi and related cross-coupling reactions with aryl or vinyl halides.
• Nucleophilic Addition to Carbonyls: Used for the tert-butylation of aldehydes, ketones, and imines to produce tertiary alcohols and amines.
• Asymmetric Synthesis: Serves as a reagent in stereoselective transformations when used with chiral ligands or catalysts.
• Laboratory-Scale Organic Synthesis: A valuable tool for academic and industrial R&D chemists exploring new synthetic methodologies.

Basic Information

Item	Details
Product Name	tert-Butylzinc Bromide
CAS No.	7565-59-5
Molecular Formula	C4H9BrZn
Molecular Weight	202.41 g/mol
Synonyms	Bromo(tert-butyl)zinc; Zinc, bromo(1,1-dimethylethyl)-; (tert-Butyl)zinc bromide; Di-tert-butylzinc (common precursor); t-BuZnBr; tert-Butyl zinc bromide; 1,1-Dimethylethylzinc bromide
EINECS	Contact for details

Quality Control

Our tert-Butylzinc Bromide is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including titration, NMR, and GC analysis. A Certificate of Analysis (COA) detailing purity, solvent content, and other critical parameters is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. This product is moisture-sensitive (hygroscopic) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for extended stability. Handle and open containers only in a controlled, moisture-free environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (in solvent)	Typically 0.5 M to 1.0 M in hexanes/THF
Assay (Titration)	≥ 95%
Identity (NMR)	Conforms to structure
Purity (GC)	≥ 98% (by GC area)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.