Description

4-Bromo-2-Fluorophenylzinc Iodide is a versatile organozinc reagent, specifically a functionalized arylzinc halide, widely used in modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in the synthesis of complex, multi-substituted aromatic and heteroaromatic compounds. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality building blocks for cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via Negishi, Suzuki-Miyaura, and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used to construct fluorinated and brominated aromatic cores found in modern herbicides, fungicides, and pesticides, enhancing their biological activity and environmental profile.
• Ligand and Material Science: Serves as a precursor for creating specialized ligands for catalysis and for synthesizing functional monomers used in organic electronics and advanced polymers.
• Chemical Research & Development: An indispensable tool in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities for screening libraries.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fluorinated and brominated fine chemicals and specialty aromatics where precise functional group introduction is critical.

Basic Information

Product Name	4-Bromo-2-Fluorophenylzinc Iodide
CAS No.	352530-44-0
Molecular Formula	C6H3BrFZnI
Molecular Weight	348.26 g/mol
Synonyms	2-Fluoro-4-bromophenylzinc iodide; (4-Bromo-2-fluorophenyl)zinc iodide; Zinc, (4-bromo-2-fluorophenyl)-, iodide (1:1); 4-Bromo-2-fluoro-1-(iodozincio)benzene; 4-Bromo-2-fluorobenzenezinc iodide; 4-Bromo-2-fluorophenyl zinc iodide; 4-Bromo-2-fluorophenylzinc iodide solution; (4-Bromo-2-fluorophenyl)iodozinc
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluorophenylzinc Iodide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and concentration (typically supplied as a solution in THF or other ethereal solvents). A comprehensive Certificate of Analysis (COA) detailing assay (by titration), residual halide content, and solvent concentration is provided. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This compound is easily oxidized and highly volatile. Keep away from heat, sparks, open flames, and incompatible materials such as strong acids, oxidizing agents, and moisture. Use only in a well-ventilated fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (on an aryl basis)
Free Halide Content	< 2%
Solvent	Anhydrous Tetrahydrofuran (THF)
Water Content (KF)	< 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.