Description

(2-Chloro-5-Pyridyl)Methylzinc Chloride is a highly reactive organozinc reagent, specifically a pyridylmethylzinc chloride derivative, that serves as a critical building block in modern synthetic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, particularly in Negishi cross-coupling reactions, to construct complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise and scalable methods for introducing functionalized pyridine motifs.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex heterocyclic structures for therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that incorporate chloropyridine subunits for enhanced bioactivity.
• Material Science Precursor: Serves as a building block for creating functionalized ligands and organic electronic materials used in OLEDs and conductive polymers.
• Negishi Cross-Coupling Reactions: Primarily employed as an efficient organozinc coupling partner with various aryl, heteroaryl, and vinyl halides for C-C bond formation.
• Chemical Research & Development: A valuable tool for medicinal and process chemists exploring new synthetic routes and novel compound libraries in R&D settings.

Basic Information

Product Name	(2-Chloro-5-Pyridyl)Methylzinc Chloride
CAS No.	352530-36-0
Molecular Formula	C6H5Cl2NZn
Molecular Weight	227.38 g/mol
Synonyms	2-Chloro-5-(chlorozinciomethyl)pyridine; (5-Chloro-2-pyridinyl)methylzinc chloride; Zinc, [(5-chloro-2-pyridinyl)methyl]chloro-; (2-Chloro-5-pyridinyl)methylzinc chloride; (5-Chloro-2-pyridyl)methylzinc chloride; Chloro[(5-chloro-2-pyridyl)methyl]zinc; Pyridine, 2-chloro-5-(chlorozinciomethyl)-
EINECS	Contact for details

Quality Control

Our (2-Chloro-5-Pyridyl)Methylzinc Chloride is manufactured under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed to confirm identity, purity, and solution concentration (typically supplied as a solution in tetrahydrofuran or other suitable solvents). Certificates of Analysis (COA) detailing assay, impurity profile, and other critical parameters are provided to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and air-sensitive. For optimal stability, it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. Keep away from heat, sparks, and open flame. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance	Solution (color may vary from colorless to brown)
Identification (NMR/IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (Zinc content)	Contact for details
Water Content (KF)	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.