Description

5-Bromo-2-Methoxybenzylzinc Chloride is a versatile organozinc reagent, a key building block in modern synthetic organic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, particularly in Negishi cross-coupling reactions, which are crucial for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity, reliable intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing substituted benzyl or biaryl motifs.
• Negishi Cross-Coupling Reactions: Serves as a highly effective nucleophilic coupling partner with various aryl, heteroaryl, and vinyl halides/pseudohalides.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific bromo-methoxy benzyl structures.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: A building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring tailored organometallic chemistry.

Basic Information

Product Name	5-Bromo-2-Methoxybenzylzinc Chloride
CAS No.	352530-35-9
Molecular Formula	C8H8BrClOZn
Molecular Weight	292.89 g/mol
Synonyms	(5-Bromo-2-methoxyphenyl)methylzinc chloride; Zinc, [(5-bromo-2-methoxyphenyl)methyl]chloro-; 5-Bromo-2-methoxybenzylzinc chloride solution; (5-Bromo-o-anisyl)methylzinc chloride; 2-Methoxy-5-bromobenzylzinc chloride; Benzylzinc chloride, 5-bromo-2-methoxy-; (5-Bromo-2-methoxyphenyl)methylchlorozinc
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Methoxybenzylzinc Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is characterized by NMR (1H, 13C) and titration to confirm identity, concentration, and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality management system is designed to meet the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is moisture-sensitive and highly volatile. Keep away from heat, sparks, and open flames. Use only in a well-ventilated fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran (typical)
Assay (Titration)	≥ 95%
Identification (NMR)	Conforms to structure
Solvent (THF) Content	Balance

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.