Description

3,5-Dichlorobenzylzinc Chloride is a highly reactive organozinc reagent, specifically a benzylzinc halide, widely used in modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise and reliable building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the 3,5-dichlorobenzyl moiety into target molecules during the research and development of new active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides that incorporate halogenated benzyl groups for enhanced efficacy.
• Cross-Coupling Reactions: Serves as a nucleophilic coupling partner in Negishi, Kumada, and related palladium-catalyzed cross-coupling reactions to form new C-C bonds.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: Utilized in the synthesis of organic electronic materials, liquid crystals, and polymers where specific halogenated aromatic structures are required.
• Custom Chemical Synthesis: A versatile building block for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	3,5-Dichlorobenzylzinc Chloride
CAS No.	352530-34-8
Molecular Formula	C7H5Cl3Zn
Molecular Weight	260.84 g/mol
Synonyms	(3,5-Dichlorophenyl)methylzinc chloride; Zinc, [(3,5-dichlorophenyl)methyl]chloro-; 3,5-Dichlorobenzyl zinc chloride; (3,5-Dichlorobenzyl)chlorozinc; Benzylzinc chloride, 3,5-dichloro-; Organozinc reagent 352530-34-8
EINECS	Contact for details

Quality Control

Our 3,5-Dichlorobenzylzinc Chloride is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for zinc content and GC/HPLC analysis for purity and identity confirmation, to ensure consistency and reliability for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and solution concentration (if applicable) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, storage at 2-8°C is recommended. The container must be kept tightly sealed and allowed to reach room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution (in specified solvent)
Identification (IR/NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (organozinc content)
Moisture (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.