Description

3,5-Dimethoxybenzylzinc Chloride is a highly reactive organozinc reagent, specifically a benzylzinc halide, widely utilized in modern synthetic organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the 3,5-dimethoxybenzyl moiety into target molecules during the research and development of new drug candidates.
• Negishi Cross-Coupling Reactions: Primarily used in palladium-catalyzed couplings with organic halides (aryl, vinyl, alkyl) to form new C-C bonds with high selectivity.
• Agrochemical Active Ingredient Production: Employed in the synthesis of complex molecules for crop protection agents and herbicides.
• Ligand and Catalyst Development: Serves as a precursor in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: Used in the synthesis of organic electronic materials and liquid crystals where the dimethoxybenzyl group imparts specific electronic or steric properties.
• Fine Chemical and Specialty Chemical Manufacturing: Applied in custom synthesis and contract manufacturing for producing high-value, low-volume chemicals.

Basic Information

Product Name	3,5-Dimethoxybenzylzinc Chloride
CAS No.	352530-33-7
Molecular Formula	C9H11ClO2Zn
Molecular Weight	251.93 g/mol
Synonyms	(3,5-Dimethoxybenzyl)zinc chloride; Zinc, chloromethylbis(3,5-dimethoxyphenyl)-; 3,5-Dimethoxybenzyl zinc chloride; (3,5-Dimethoxyphenylmethyl)zinc chloride; Benzylzinc chloride, 3,5-dimethoxy-; 352530-33-7; Chloro(3,5-dimethoxybenzyl)zinc
EINECS	Contact for details

Quality Control

Every batch of 3,5-Dimethoxybenzylzinc Chloride is manufactured and analyzed under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including titration for zinc content and solution stability checks, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific purity, concentration, and solvent data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. This compound is strictly light-sensitive (protect from all light exposure) and easily oxidized (store under inert atmosphere). For optimal stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The container must be kept tightly sealed in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran (Typical)
Assay (Titration)	≥ 95%
Solvent	Tetrahydrofuran (THF)
Stability	Stable under inert atmosphere at recommended temperature

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.