Description

2,5-Dimethoxybenzylzinc Chloride is a versatile organozinc reagent, a key building block in modern synthetic organic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, specifically through Negishi cross-coupling reactions, which are critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial reagent for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in constructing novel herbicide and pesticide molecules that require specific aromatic substitution patterns.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and conductive polymers, where dimethoxybenzyl motifs are functional components.
• Fine Chemical Production: Facilitates the scalable, selective introduction of the 2,5-dimethoxybenzyl group into target molecules under mild conditions.
• Academic & R&D Laboratories: A valuable tool for methodological development in organic synthesis and exploring new catalytic transformations.

Basic Information

Product Name	2,5-Dimethoxybenzylzinc Chloride
CAS No.	352530-32-6
Molecular Formula	C9H11ClO2Zn
Molecular Weight	251.99 g/mol
Synonyms	(2,5-Dimethoxybenzyl)zinc chloride; Zinc, chlorobis(2,5-dimethoxyphenyl)methyl-; 2,5-Dimethoxybenzylzinc chloride solution; (2,5-Dimethoxybenzyl)zinc chloride solution; Benzene, 1-(chlorozinciomethyl)-2,5-dimethoxy-; 2,5-Dimethoxybenzyl zinc chloride; (2,5-Dimethoxyphenyl)methylzinc chloride
EINECS	Contact for details

Quality Control

Every batch of 2,5-Dimethoxybenzylzinc Chloride is manufactured and tested under strict quality management protocols to ensure consistency and reliability for critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) that detail purity, concentration (for solutions), and impurity profiles, typically determined by advanced analytical techniques including NMR, titration, and ICP-MS for metal content. Our quality commitment supports compliance with cGMP and ICH guidelines where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For solutions, maintain at the recommended temperature, typically between 2°C and 8°C for extended stability. Keep away from heat, sparks, and open flame. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance (Solution)	Colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran (typical, other solvents available)
Assay (Titration)	≥ 95.0%
Zinc Content	Confirmatory
Identification (NMR)	Conforms to structure
Water Content (Karl Fischer)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.