Description

2-Cyano-3-Fluorophenylzinc Iodide is a highly reactive organozinc reagent, specifically an arylzinc halide, used as a key building block in modern synthetic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, to introduce the valuable 2-cyano-3-fluorophenyl moiety into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise functionalization of aromatic systems.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and nitrile-substituted aromatic rings, which are common in drug discovery for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine and nitrile groups contribute to biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials through controlled coupling reactions.
• Negishi Cross-Coupling Reactions: Acts as the organozinc component in palladium-catalyzed couplings with various organic electrophiles (e.g., aryl halides, acid chlorides) to form biaryl and other complex structures.
• Synthesis of Fluorinated Liquid Crystals: Key building block for introducing fluorine and cyano groups into liquid crystal molecules, tuning their dielectric anisotropy and phase behavior for display applications.
• Custom Chemical Synthesis: Employed in contract research and manufacturing organizations (CROs/CMOs) for the bespoke synthesis of complex, multi-functional aromatic compounds.

Basic Information

Item	Details
Product Name	2-Cyano-3-Fluorophenylzinc Iodide
CAS No.	352525-67-8
Molecular Formula	C7H3FIZnN
Molecular Weight	288.41 g/mol
Synonyms	(2-Cyano-3-fluorophenyl)zinc iodide; Zinc, (2-cyano-3-fluorophenyl)-, iodide; 3-Fluoro-2-cyanophenylzinc iodide; 2-Fluoro-6-cyanophenylzinc iodide; (3-Fluoro-2-cyanophenyl)zinc iodide; Organozinc reagent 352525-67-8; Arylzinc halide CAS 352525-67-8
EINECS	Contact for details

Quality Control

Every batch of 2-Cyano-3-Fluorophenylzinc Iodide is manufactured and tested under strict quality protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including titration for active zinc content and analytical techniques to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, this reagent is best handled under an inert atmosphere (argon or nitrogen) and stored with appropriate desiccants. Recommended long-term storage temperature is between 2°C and 8°C. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to beige suspension or solid
Identification (IR)	Conforms to structure
Assay (Zinc Content)	≥ 0.4 M in THF (or as specified)
Purity (HPLC)	≥ 95% (by area)
Solvent (Typical)	Tetrahydrofuran (THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.