Description

4-Bromo-3-Fluorophenylzinc Iodide 0.5M is a highly reactive organozinc reagent, a crucial building block for advanced organic synthesis. This compound matters for its ability to facilitate efficient carbon-carbon bond formation, specifically in Negishi cross-coupling reactions, enabling the precise construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need it for the development of novel active ingredients and functional molecules where the introduction of a halogenated aryl group is required.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing complex, halogenated biaryl and heterobiaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific halogenated phenyl moieties for bioactivity.
• Material Science & OLED Development: Employed in the creation of advanced organic electronic materials, including charge-transport layers and emissive materials for OLED displays.
• Negishi Cross-Coupling Reactions: Serves as a superior alternative to other organometallics for coupling with a wide range of aryl, heteroaryl, and vinyl halides under mild conditions.
• Ligand and Catalyst Development: Useful for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and polymerization.
• Custom Chemical & Contract Manufacturing: A vital tool for custom synthesis houses and CROs/CMOs producing bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	4-Bromo-3-Fluorophenylzinc Iodide 0.5M
CAS No.	352525-65-6
Molecular Formula	C6H3BrFZnI
Molecular Weight	Contact for details
Synonyms	Zinc, (4-bromo-3-fluorophenyl)-, iodide (1:1); (4-Bromo-3-fluorophenyl)zinc iodide; 4-Bromo-3-fluorophenylzinc iodide solution; 3-Fluoro-4-bromophenylzinc iodide; 0.5M 4-Bromo-3-fluorophenylzinc iodide in THF; Organozinc reagent B3FPhZnI; Negishi Reagent
EINECS	Contact for details

Quality Control

Every batch of our 4-Bromo-3-Fluorophenylzinc Iodide 0.5M undergoes rigorous quality testing to ensure consistency and reliability for sensitive synthetic applications. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing key parameters such as concentration, active zinc content, and halide impurity profiles. Our quality management system is designed to meet the stringent demands of GMP and ISO-guided environments for research and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. The solution is highly volatile, moisture-sensitive, and easily oxidized. Keep away from heat, sparks, open flames, and strong oxidizing agents. Use only in a well-ventilated fume hood.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 95% (as C6H3BrFZnI)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.