Description

1-Boc-5-Fluoroindole-2-Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected indole scaffold with both boronic acid and fluorine functional groups. This compound is critically important as a versatile building block in modern synthetic chemistry, enabling the construction of complex molecules through efficient cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those containing indole or fluorinated heterocyclic structures.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid moiety enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker molecules and warhead components for targeted protein degradation therapeutics.
• Kinase Inhibitor Research: Serves as a precursor for the synthesis of potential kinase inhibitors, leveraging the indole core common in many such compounds.
• Fluorinated Compound Libraries: Essential for creating libraries of fluorinated compounds for high-throughput screening in drug discovery programs.
• Material Science Research: Potential use in the synthesis of organic electronic materials and advanced polymers requiring specific fluorinated aromatic units.

Basic Information

Product Name	1-Boc-5-Fluoroindole-2-Boronic Acid
CAS No.	352359-23-0
Molecular Formula	C₁₃H₁₅BFNO₄
Molecular Weight	287.07 g/mol
Synonyms	1-Boc-5-Fluoroindole-2-boronic acid; 5-Fluoro-1-[(tert-butoxy)carbonyl]-1H-indole-2-boronic acid; tert-Butyl 5-fluoro-2-boronoindole-1-carboxylate; 1-(tert-Butoxycarbonyl)-5-fluoroindole-2-boronic acid; 5-Fluoro-1-Boc-indole-2-boronic acid; 1-Boc-5-F-indole-2-BA; 1-Boc-5-Fluoro-1H-indole-2-boronic acid; 2-Borono-5-fluoro-1H-indole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Fluoroindole-2-Boronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.