Description

Ethanone, 2,2,2-Trifluoro-1-(3-Hydroxy-4-Methylphenyl)- (9Ci) is a specialized trifluoromethyl ketone derivative, a key building block in advanced organic synthesis. Its molecular structure, featuring both a phenolic hydroxyl group and a highly electrophilic trifluoroacetyl moiety, makes it a versatile intermediate for creating complex molecules with enhanced properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of drug candidates, particularly those requiring the incorporation of a trifluoromethyl group to improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and environmental persistence profiles.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of advanced polymers and functional materials with specific optical or electronic properties derived from its aromatic and fluorinated components.
• Chemical Biology Probes: Utilized to develop activity-based probes and inhibitors for studying enzyme mechanisms, leveraging its reactive ketone functionality.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-(3-Hydroxy-4-Methylphenyl)- (9Ci)
CAS No.	352339-65-2
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	2,2,2-Trifluoro-1-(3-hydroxy-4-methylphenyl)ethanone; 1-(3-Hydroxy-4-methylphenyl)-2,2,2-trifluoroethanone; 3-Hydroxy-4-methyl-2,2,2-trifluoroacetophenone; 4-Methyl-3-hydroxy-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(3-hydroxy-p-tolyl)ethanone; TFHMP; Trifluoromethyl ketone derivative of p-cresol
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this high-purity intermediate. Every batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality system is designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and documentation meet rigorous industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.