Description

3-(2-Fluoro-Phenoxymethyl)-4-Methoxy-Benzaldehyde is a specialized aromatic aldehyde building block of significant interest in advanced organic synthesis. Its molecular structure, featuring a fluorinated phenoxymethyl ether linkage, makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and inflammatory pathways.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and plant growth regulators, leveraging the fluorine atom for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated aromatic cores for electronic materials, contributing to improved charge transport and emission properties in display technologies.
• Polymer & Resin Modifier: Acts as a functional monomer or cross-linking agent to introduce specific aromatic and ether functionalities into polymer backbones, enhancing thermal and chemical resistance.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions, nucleophilic additions, and reductive amination protocols to create diverse chemical libraries for screening.

Basic Information

Product Name	3-(2-Fluoro-Phenoxymethyl)-4-Methoxy-Benzaldehyde
CAS No.	351366-06-8
Molecular Formula	C15H13FO3
Molecular Weight	260.26 g/mol
Synonyms	4-Methoxy-3-[(2-fluorophenoxy)methyl]benzaldehyde; 3-[(2-Fluorophenoxy)methyl]-4-methoxybenzaldehyde; 2-Fluoro-α-[(4-methoxy-3-formylphenoxy)methyl]benzene; Benzaldehyde, 3-[(2-fluorophenoxy)methyl]-4-methoxy-; 351366-06-8; 3-(2-Fluorophenoxymethyl)-4-methoxybenzaldehyde; 4-Methoxy-3-(2-fluorophenoxymethyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our production of 3-(2-Fluoro-Phenoxymethyl)-4-Methoxy-Benzaldehyde adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is analyzed via modern analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.