Description

1-Chloroisoquinoline-4-Carboxaldehyde is a versatile and high-value heterocyclic building block, essential for advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the aldehyde and chlorinated quinoline moieties serve as key handles for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinases and other enzymatic pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand Synthesis: Serves as a starting material for creating sophisticated chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic semiconductors, fluorescent dyes, and photoactive polymers.
• Cross-Coupling Reactions: The chlorine atom is an excellent site for palladium-catalyzed cross-coupling (e.g., Suzuki, Buchwald-Hartwig) to introduce diverse substituents.
• Nucleophilic Aromatic Substitution: Reacts with various nucleophiles to yield substituted isoquinoline derivatives.
• Condensation Reactions: The aldehyde group participates in condensations (e.g., with amines, hydrazines) to form imines, hydrazones, and other Schiff bases.

Basic Information

Product Name	1-Chloroisoquinoline-4-Carboxaldehyde
CAS No.	351324-72-6
Molecular Formula	C10H6ClNO
Molecular Weight	191.61 g/mol
Synonyms	4-Isoquinolinecarboxaldehyde, 1-chloro-; 1-Chloro-4-isoquinolinecarboxaldehyde; 1-Chloro-4-formylisoquinoline; 1-Chloroisoquinoline-4-carbaldehyde; 4-Formyl-1-chloroisoquinoline; 351324-72-6; 1-Chloro-isoquinoline-4-carbaldehyde
EINECS	Contact for details

Quality Control

Our 1-Chloroisoquinoline-4-Carboxaldehyde is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.