Description

n-[3-(Trimethylsilyl)-2-Propynyl]Phthalimide is a specialized organosilicon building block featuring a phthalimide-protected propargylamine moiety. This compound is valued for its dual functionality, serving as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and advanced material research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring propargylamine or silyl-protected alkyne functionalities.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive alkyne group for cycloaddition and coupling reactions.
• Material Science Research: Serves as a precursor for polymers and advanced materials, where the trimethylsilyl-protected alkyne can be deprotected and used in click chemistry (e.g., CuAAC) to create cross-linked networks.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Peptide Mimetics and Bioconjugation: The phthalimide group can be used as an amine-protecting strategy in peptide synthesis, while the alkyne enables bioorthogonal labeling strategies.
• Academic and Industrial R&D: A versatile reagent for methodological development in organic synthesis, including Sonogashira coupling and other metal-catalyzed transformations.

Basic Information

Product Name	n-[3-(Trimethylsilyl)-2-Propynyl]Phthalimide
CAS No.	351029-12-4
Molecular Formula	C₁₄H₁₇NO₂Si
Molecular Weight	259.38 g/mol
Synonyms	N-(3-Trimethylsilyl-2-propynyl)phthalimide; 2-[3-(Trimethylsilyl)prop-2-yn-1-yl]isoindoline-1,3-dione; 1,3-Dioxo-2-[3-(trimethylsilyl)-2-propynyl]isoindoline; Phthalimide, N-[3-(trimethylsilyl)-2-propynyl]-; TMS-Propargyl Phthalimide; N-Propargylphthalimide, 3-trimethylsilyl-; (3-Trimethylsilyl-2-propynyl)phthalimide
EINECS	Contact for details

Quality Control

Our n-[3-(Trimethylsilyl)-2-Propynyl]Phthalimide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.