Description

3-(Difluoromethoxy)Benzenesulfonyl Chloride is a high-purity, reactive organosulfur intermediate characterized by its sulfonyl chloride functional group and difluoromethoxy substituent. This compound is a critical building block in advanced organic synthesis, enabling the introduction of the sulfonamide moiety into target molecules. It is primarily sought after by research and development teams and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including potential enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the sulfonamide group contributes to biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialized polymers with unique surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to clients.

Basic Information

Product Name	3-(Difluoromethoxy)Benzenesulfonyl Chloride
CAS No.	351003-38-8
Molecular Formula	C7H5ClF2O3S
Molecular Weight	242.63 g/mol
Synonyms	m-(Difluoromethoxy)Benzenesulfonyl Chloride; 3-(Difluoromethoxy)benzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 3-(difluoromethoxy)-; 1-(Difluoromethoxy)-3-(chlorosulfonyl)benzene; α,α-Difluoro-m-cresolsulfonyl chloride; 3-DFMOBS-Cl; DFMOBS-Cl
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.