Description

2-Bromo-3-{[tert-Butyl(Dimethyl)Silyl]Oxy}-6-Hydroxybenzenecarbaldehyde is a sophisticated, multi-functional aromatic aldehyde derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic protection of the phenol group with a tert-butyldimethylsilyl (TBDMS) ether, which provides excellent stability and selectivity for complex multi-step syntheses. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecular architectures where precise functional group manipulation is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of novel drug candidates with complex phenolic backbones.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its halogen and protected hydroxy groups allow for targeted chemical modifications.
• Material Science Research: Serves as a precursor for synthesizing specialized organic ligands, monomers, or functional materials requiring specific aromatic aldehyde chemistry.
• Chemical Biology & Proteomics: Utilized as a derivatization agent or a scaffold for creating molecular probes and tags due to its reactive aldehyde and bromine functional groups.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis, including cross-coupling reactions and protective group chemistry studies.

Basic Information

Product Name	2-Bromo-3-{[tert-Butyl(Dimethyl)Silyl]Oxy}-6-Hydroxybenzenecarbaldehyde
CAS No.	347840-64-6
Molecular Formula	C₁₃H₁₉BrO₃Si
Molecular Weight	331.28 g/mol
Synonyms	2-Bromo-3-[(tert-butyldimethylsilyl)oxy]-6-hydroxybenzaldehyde; 2-Bromo-6-hydroxy-3-[(tert-butyldimethylsilyl)oxy]benzaldehyde; 3-[(tert-Butyldimethylsilyl)oxy]-2-bromo-6-hydroxybenzaldehyde; Benzaldehyde, 2-bromo-6-hydroxy-3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; TBDMS-protected 2-bromo-6-hydroxybenzaldehyde derivative
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-3-{[tert-Butyl(Dimethyl)Silyl]Oxy}-6-Hydroxybenzenecarbaldehyde adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment, supporting compliance in cGMP and research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.