Description

4,4,5,5-Tetramethyl-2-(1-Propyn-1-Yl)-1,3,2-Dioxaborolane is a specialized organoboron reagent, specifically a pinacol-protected alkynylboronic ester, widely used in advanced synthetic chemistry. Its primary value lies in enabling efficient and selective carbon-carbon bond formation, particularly in the synthesis of complex organic molecules and functional materials. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require high-purity building blocks for Suzuki-Miyaura cross-coupling and other metal-catalyzed reactions.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex molecular architectures in active pharmaceutical ingredient (API) development.
• Agrochemical Research: Used in the synthesis of novel crop protection agents and herbicides.
• Materials Science: Employed in the creation of organic electronic materials, polymers, and liquid crystals via cross-coupling reactions.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-handleable source of the alkynyl group for palladium-catalyzed couplings with aryl or vinyl halides.
• Academic & Industrial R&D: A fundamental reagent in medicinal chemistry and methodology development laboratories.
• Fine Chemical Production: Used in the multi-step synthesis of specialty chemicals and advanced intermediates.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(1-Propyn-1-Yl)-1,3,2-Dioxaborolane
CAS No.	347389-75-7
Molecular Formula	C11H19BO2
Molecular Weight	194.08 g/mol
Synonyms	2-(Prop-1-yn-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Propynylboronic acid pinacol ester; Pinacol (1-propynyl)boronate; 1-Propynylboronic acid, pinacol ester; Alkynylboronic ester; Prop-1-yn-1-ylboronic acid pinacol ester; 1-Propynyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(1-Propyn-1-Yl)-1,3,2-Dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is subjected to rigorous analytical testing, including NMR, GC, and HPLC analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.