Description

2-Ethynyl-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-value organoboron building block, specifically a pinacol-protected ethynylboronic ester. This compound is a critical reagent in modern synthetic chemistry, enabling efficient carbon-carbon bond formation. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for introducing an ethynyl group into aromatic and heteroaromatic systems to create conjugated alkynes.
• Pharmaceutical Intermediate Synthesis: Used in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and plant growth regulators with specific activity profiles.
• Material Science & OLED Development: Serves as a precursor for constructing organic semiconductors, light-emitting materials, and conductive polymers.
• Chemical Biology & Probe Development: Utilized for labeling biomolecules via click chemistry (copper-catalyzed azide-alkyne cycloaddition) due to its terminal alkyne functionality.
• Academic & Contract Research: A staple in academic laboratories and CROs for methodological development and library synthesis in drug discovery programs.

Basic Information

Product Name	2-Ethynyl-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	347389-74-6
Molecular Formula	C8H13BO2
Molecular Weight	152.00 g/mol
Synonyms	Ethynylpinacolborane; 2-Ethynyl-2,3,3,4,4,5-hexamethyl-1,3,2-dioxaborolane; Ethynylboronic Acid Pinacol Ester; Pinacol Ethynylboronate; 4,4,5,5-Tetramethyl-2-(ethynyl)-1,3,2-dioxaborolane; 2-Ethynyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-Ethynyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 2-Ethynyl-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, which is critical for sensitive cross-coupling reactions. All materials are characterized by NMR (1H, 11B, 13C), GC/HPLC, and FTIR analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage or when opening containers to prevent hydrolysis and maintain reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.