Description

(1R,5S,6R)-Rel-5-(1-Ethylpropoxy)-7-Oxabicyclo[4.1.0]Hept-3-Ene-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and bicyclic oxirane structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its defined stereocenters and functional groups enable precise chemical transformations. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated chiral building blocks.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of proprietary drug candidates and complex APIs.
• Organic Synthesis Research: Used in academic and industrial R&D for exploring new reaction pathways involving strained oxirane (epoxide) rings.
• Asymmetric Catalysis Studies: Serves as a substrate or a ligand precursor in the development of new chiral catalysts and methodologies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to modify the core scaffold of potential drug molecules.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes in pilot plants and kilo-labs.
• Fine Chemical Production: Acts as a building block for the manufacture of other high-value, specialty chemicals.

Basic Information

Product Name	(1R,5S,6R)-Rel-5-(1-Ethylpropoxy)-7-Oxabicyclo[4.1.0]Hept-3-Ene-3-Carboxylic Acid Ethyl Ester
CAS No.	347378-74-9
Molecular Formula	C15H22O4
Molecular Weight	266.33 g/mol
Synonyms	Ethyl (1R,5S,6R)-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate; Rel-(1R,5S,6R)-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester; 7-Oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid, 5-(1-ethylpropoxy)-, ethyl ester, (1R,5S,6R)-rel-; Bicyclic Oxirane Ester Intermediate; CAS 347378-74-9
EINECS	Contact for details

Quality Control

Our (1R,5S,6R)-Rel-5-(1-Ethylpropoxy)-7-Oxabicyclo[4.1.0]Hept-3-Ene-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be stored away from light. It is also recommended to store under an inert atmosphere (e.g., nitrogen or argon) to minimize potential oxidation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.