Description

1-Chloro-2-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Benzene is a high-purity organoboron reagent, specifically a pinacol-protected arylboronic ester. This compound is valued for its enhanced stability and handling properties compared to its boronic acid counterpart, making it a critical intermediate in modern synthetic chemistry. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for creating biaryl and heterobiaryl structures, which are core motifs in many active pharmaceutical ingredients (APIs) and organic electronic materials.
• Pharmaceutical Intermediate: Used in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and as a precursor for boron-doped materials.
• Material Science Research: Utilized in the development of organic light-emitting diodes (OLEDs), semiconductors, and liquid crystals.
• Chemical Biology Probes: Acts as a handle for bioconjugation and the synthesis of molecules used to study biological processes.

Basic Information

Product Name	1-Chloro-2-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Benzene
CAS No.	346656-42-6
Molecular Formula	C13H18BClO2
Molecular Weight	252.54 g/mol
Synonyms	2-Chlorophenylboronic acid pinacol ester; (2-Chlorophenyl)boronic acid pinacol ester; 2-Chlorophenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(2-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; 2-Chloro-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; Pinacol (2-chlorophenyl)boronate
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.