Description

1-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-2-Fluorobenzene is a high-purity organoboron reagent, specifically a cyclic boronic ester derivative, essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient and selective formation of carbon-carbon bonds. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel fluorinated compounds and complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for introducing the 2-fluorophenyl moiety into complex molecules under mild conditions.
• Pharmaceutical Intermediate Synthesis: Used in the research and production of active pharmaceutical ingredients (APIs) containing fluorinated aromatic systems.
• Agrochemical Development: Employed in the synthesis of novel herbicides, fungicides, and insecticides where fluorination enhances biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and catalysts used in asymmetric synthesis and polymerization.
• Material Science Research: Used in the creation of fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and optical properties.
• Chemical Biology & Probe Development: Facilitates the synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	1-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-2-Fluorobenzene
CAS No.	346656-39-1
Molecular Formula	C12H16BFO2
Molecular Weight	222.07 g/mol
Synonyms	2-Fluorophenylboronic acid 5,5-dimethyl-1,3,2-dioxaborinane ester; 2-Fluorophenyl-5,5-dimethyl-1,3,2-dioxaborinane; (2-Fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 2-Fluoro-1-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzene; 2-Fluorophenyl MIDA Boronate (related class); 2-Fluorobenzene-1-boronic acid cyclic ester with neopentyl glycol; 2-Fluorophenylboronic acid neopentyl glycol ester
EINECS	Contact for details

Quality Control

Our 1-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.