Description

3-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene is a high-value, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring chlorine, iodine, and a trifluoromethoxy substituent, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and chlorine atoms provide orthogonal reactivity for sequential Suzuki, Stille, and Buchwald-Hartwig amination reactions to build complex biaryl and heteroaryl systems.
• Ligand and Catalyst Development: Utilized as a scaffold for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.
• Fluorine Chemistry Studies: An important compound for investigating the influence of the trifluoromethoxy group on reactivity and physicochemical properties in medicinal chemistry.

Basic Information

Product Name	3-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene
CAS No.	345226-19-9
Molecular Formula	C7H3ClF3IO
Molecular Weight	321.45 g/mol
Synonyms	1-Chloro-2-iodo-4-(trifluoromethoxy)benzene; 3-Chloro-4-iodophenyl trifluoromethyl ether; 4-Trifluoromethoxy-3-chloroiodobenzene; 2-Iodo-5-chlorophenyl trifluoromethyl ether; Benzene, 3-chloro-4-iodo-1-(trifluoromethoxy)-; 3-Chloro-4-iodo-alpha,alpha,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.