Description

Carbamic Acid, [(2S)-2-Fluoro-3-Hydroxypropyl]-, 1,1-Dimethylethyl Ester (9Ci) is a high-purity, chiral fluorinated building block of significant interest in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting complex disease pathways. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of fluorinated drug candidates, where its specific stereochemistry and functional groups are critical for biological activity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of fluorinated pharmaceuticals, including potential antiviral, anticancer, and central nervous system (CNS) agents.
• Protease Inhibitor Synthesis: Used in the construction of complex molecules designed to inhibit specific proteases, a common target in modern drug discovery.
• Peptidomimetic Chemistry: Serves as a fluorinated amino acid derivative for creating stable peptide analogs with enhanced metabolic stability and membrane permeability.
• Labeled Compound Precursor: Acts as a starting material for the synthesis of compounds containing fluorine-18 (18F) for use in Positron Emission Tomography (PET) imaging tracers.
• Agrochemical Research: Employed in the discovery of new fluorinated agrochemicals, where the fluorine atom can improve lipophilicity and biological activity.
• Material Science Research: Investigated as a monomer or modifier for introducing fluorine into specialty polymers to alter surface properties and stability.

Basic Information

Product Name	Carbamic Acid, [(2S)-2-Fluoro-3-Hydroxypropyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	344413-84-9
Molecular Formula	C8H16FNO3
Molecular Weight	193.22 g/mol
Synonyms	(S)-tert-Butyl (2-fluoro-3-hydroxypropyl)carbamate; (2S)-2-Fluoro-3-hydroxypropylcarbamic acid tert-butyl ester; tert-Butyl N-[(2S)-2-fluoro-3-hydroxypropyl]carbamate; (S)-tert-Butyl (2-fluoro-3-hydroxypropyl)carbamate; Boc-L-2-fluoro-3-hydroxypropylamine; (S)-3-((tert-Butoxycarbonyl)amino)-2-fluoropropan-1-ol; N-Boc-2-fluoro-3-hydroxypropylamine (S-isomer); 344413-84-9
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(2S)-2-Fluoro-3-Hydroxypropyl]-, 1,1-Dimethylethyl Ester (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and MS for structural confirmation, to ensure compliance with research and cGMP-grade standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.