Description

p-[(2R)-3-Amino-2-Fluoropropyl]Phosphinic Acid is a high-purity, chiral organophosphorus compound featuring both amino and fluoropropyl functional groups. This unique structure makes it a critical advanced pharmaceutical intermediate for the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) therapeutics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of GABAB receptor agonists and related neurological agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new drug candidates targeting neurological pathways.
• Preclinical Development: Serves as a critical starting material for producing active pharmaceutical ingredients (APIs) in small-scale GMP campaigns.
• Biochemical Tool Compound: Utilized in biochemical assays to study receptor-ligand interactions and enzyme mechanisms.
• Asymmetric Synthesis: The chiral (2R) configuration provides a stereocenter for the production of enantiomerically pure compounds.

Basic Information

Product Name	p-[(2R)-3-Amino-2-Fluoropropyl]Phosphinic Acid
CAS No.	344413-67-8
Molecular Formula	C3H9FNO2P
Molecular Weight	141.08 g/mol
Synonyms	(R)-3-Amino-2-fluoropropylphosphinic acid; (2R)-3-Amino-2-fluoropropylphosphinic acid; (R)-3-Amino-2-fluoropropylphosphinic acid; 2-Fluoro-3-aminopropylphosphinic acid (R-enantiomer); (R)-AFPPA; p-[(2R)-3-Amino-2-fluoropropyl]phosphinic acid; GABAB receptor ligand intermediate; (R)-3-Amino-2-fluoropropanephosphonic acid (common misnomer).
EINECS	Contact for details

Quality Control

Our production of p-[(2R)-3-Amino-2-Fluoropropyl]Phosphinic Acid adheres to stringent quality protocols suitable for research and pre-clinical applications. Every batch is characterized and tested to ensure high chiral purity and chemical identity. Comprehensive analytical data, including HPLC, NMR, and optical rotation, are documented in the batch-specific Certificate of Analysis (COA), which is available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (R-enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.