Description

2-(1-Amino-2-[3-(Trifluoromethyl)Phenoxy]Ethylidene)Malononitrile is a specialized organic intermediate featuring a unique trifluoromethylphenoxy and malononitrile functional group architecture. This compound matters for its role as a critical building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structure imparts valuable electronic and steric properties. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular frameworks.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing specific receptor binding profiles.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Advanced Material Development: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, or organic semiconductors.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new organic reactions and constructing complex heterocyclic compounds.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments due to the conjugated system formed by the malononitrile group.

Basic Information

Product Name	2-(1-Amino-2-[3-(Trifluoromethyl)Phenoxy]Ethylidene)Malononitrile
CAS No.	343375-42-8
Molecular Formula	C₁₃H₉F₃N₃O
Molecular Weight	280.23 g/mol
Synonyms	2-(1-Amino-2-(3-(trifluoromethyl)phenoxy)ethylidene)malononitrile; 2-(1-Amino-2-(m-trifluoromethylphenoxy)ethylidene)malononitrile; 2-(Amino(3-(trifluoromethyl)phenoxy)methylene)malononitrile; 2-(1-Amino-2-(3-trifluoromethylphenoxy)vinylidene)malononitrile; (Z)-2-(1-Amino-2-(3-(trifluoromethyl)phenoxy)ethylidene)malononitrile; CAS 343375-42-8; α-Amino-β-(3-trifluoromethylphenoxy)acrylonitrile derivative
EINECS	Contact for details

Quality Control

Our 2-(1-Amino-2-[3-(Trifluoromethyl)Phenoxy]Ethylidene)Malononitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.