Description

Benzenemethanamine, 2-(2,2,2-Trifluoroethoxy)- is a specialized fluorinated aromatic amine building block of significant interest in advanced organic synthesis. This compound matters for its unique structural motif, combining a benzylamine core with a trifluoroethoxy substituent, which imparts distinct electronic and physicochemical properties. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the construction of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioactivity, metabolic stability, and lipophilicity.

Application

• As a key pharmaceutical intermediate in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Utilized as a versatile building block for the preparation of advanced agrochemicals, such as herbicides and fungicides, leveraging the properties of fluorine.
• Employed in material science research for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Serves as a precursor for the synthesis of complex ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Used in academic and industrial R&D for structure-activity relationship (SAR) studies and medicinal chemistry optimization programs.

Basic Information

Product Name	Benzenemethanamine, 2-(2,2,2-Trifluoroethoxy)-
CAS No.	342816-26-6
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	2-[(2,2,2-Trifluoroethoxy)methyl]aniline; 1-[2-(Trifluoroethoxy)phenyl]methanamine; 2-(Trifluoroethoxymethyl)aniline; α-(2-Aminophenyl)-2,2,2-trifluoroethyl ether; 2-(Aminomethyl)-1-(2,2,2-trifluoroethoxy)benzene; 2-(2,2,2-Trifluoroethoxy)benzylamine; (2-(Trifluoroethoxymethyl)phenyl)amine
EINECS	Contact for details

Quality Control

Our Benzenemethanamine, 2-(2,2,2-Trifluoroethoxy)- is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality parameters. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and oxidizing agents. Due to its amine functionality and light-sensitive nature, prolonged exposure to air, moisture, or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.