Description

5-(2-Thienyl)Nicotinaldehyde is a high-purity heterocyclic aldehyde building block of significant interest in advanced organic synthesis. Its core value lies in its bifunctional molecular architecture, combining a nicotinaldehyde moiety with a thiophene ring, which makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry and ligand synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the synthesis of new generation herbicides and fungicides, leveraging its heterocyclic structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated chelating ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic semiconductors and conductive polymers due to the electron-rich thiophene unit.
• Chemical Biology: Utilized as a probe or linker molecule in bioconjugation and the development of chemical tools for biological study.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory synthesis in university and CRO laboratory settings.

Basic Information

Product Name	5-(2-Thienyl)Nicotinaldehyde
CAS No.	342601-29-0
Molecular Formula	C10H7NOS
Molecular Weight	189.23 g/mol
Synonyms	5-(Thiophen-2-yl)pyridine-3-carbaldehyde; 3-Formyl-5-(2-thienyl)pyridine; 5-(2-Thienyl)-3-pyridinecarboxaldehyde; Nicotinaldehyde, 5-(2-thienyl)-; 5-(Thiophen-2-yl)nicotinaldehyde; 5-(2-Thienyl)nicotinaldehyde; 2-Thienylnicotinaldehyde
EINECS	Contact for details

Quality Control

Our 5-(2-Thienyl)Nicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). For long-term storage, consider storing under an inert gas such as argon or nitrogen. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.