Description

2-Oxazolidinone,4-(Hydroxymethyl)-3,5-Dimethyl-,(4S,5S)-(9Ci) is a high-value, stereochemically defined chiral building block and intermediate. This compound is critical for the synthesis of complex molecules where precise stereochemistry is essential for biological activity and material properties. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and advanced materials. The compound is supplied with CAS No. 341512-50-3.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel antibiotics, particularly oxazolidinone-class antibacterial agents like linezolid analogs.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure pesticides and herbicides, where specific stereochemistry can enhance efficacy and reduce environmental impact.
• Asymmetric Catalysis: Serves as a precursor or ligand for chiral catalysts used in stereoselective organic transformations.
• Material Science Research: Employed in the development of chiral polymers or liquid crystals with specific optical properties.
• Academic & R&D: A valuable tool for medicinal chemistry programs and synthetic methodology research in university and corporate laboratories.
• Process Chemistry: Used in scaling up routes to chiral drugs, providing a controlled stereogenic center for consistent batch-to-batch quality.

Basic Information

Product Name	2-Oxazolidinone,4-(Hydroxymethyl)-3,5-Dimethyl-,(4S,5S)-(9Ci)
CAS No.	341512-50-3
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(4S,5S)-4-(Hydroxymethyl)-3,5-dimethyl-1,3-oxazolidin-2-one; (4S,5S)-4-(Hydroxymethyl)-3,5-dimethyl-2-oxazolidinone; (4S-cis)-4-(Hydroxymethyl)-3,5-dimethyl-2-oxazolidinone; cis-4-(Hydroxymethyl)-3,5-dimethyl-2-oxazolidinone; Chiral Oxazolidinone Building Block; Linezolid Intermediate
EINECS	Contact for details

Quality Control

Every batch of our (4S,5S)-4-(Hydroxymethyl)-3,5-dimethyl-2-oxazolidinone is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high chemical and chiral purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality management system supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.