Description

2-Bromo-1-(4-Chloro-2-Fluoro-5-Methylphenyl)-1-Ethanone is a high-purity halogenated aromatic ketone building block, essential for advanced organic synthesis. This compound is valued for its reactive bromoacetyl group and strategically substituted phenyl ring, which facilitate the construction of complex molecular architectures. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used as a precursor for developing new herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Bromo-1-(4-Chloro-2-Fluoro-5-Methylphenyl)-1-Ethanone
CAS No.	338982-26-6
Molecular Formula	C9H7BrClFO
Molecular Weight	265.51 g/mol
Synonyms	2-Bromo-1-(4-chloro-2-fluoro-5-methylphenyl)ethanone; 2-Bromo-4'-chloro-2'-fluoro-5'-methylacetophenone; 1-(4-Chloro-2-fluoro-5-methylphenyl)-2-bromoethanone; α-Bromo-4-chloro-2-fluoro-5-methylacetophenone; 338982-26-6; Ethanone, 2-bromo-1-(4-chloro-2-fluoro-5-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(4-Chloro-2-Fluoro-5-Methylphenyl)-1-Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require desiccant or storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.