Description

1-Methyl-2-([3-(Trifluoromethyl)Benzyl]Sulfanyl)-1H-Indole-3-Carbaldehyde is a high-value, multi-functional indole derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in its unique molecular architecture, combining an indole scaffold with a trifluoromethylbenzyl sulfide moiety, making it indispensable for constructing complex pharmacophores. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials. Its precise structure enables targeted modifications, facilitating the exploration of new chemical entities with potential biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the bioactivity of the indole core and the lipophilicity imparted by the trifluoromethyl group.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialized polymers and organic electronic materials.
• Chemical Biology Probe: Utilized in academic and industrial research to study enzyme inhibition and protein-ligand interactions due to its modifiable aldehyde group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring complex heterocyclic chemistry.

Basic Information

Product Name	1-Methyl-2-([3-(Trifluoromethyl)Benzyl]Sulfanyl)-1H-Indole-3-Carbaldehyde
CAS No.	338416-41-4
Molecular Formula	C18H14F3NOS
Molecular Weight	349.37 g/mol
Synonyms	1-Methyl-2-[[3-(trifluoromethyl)phenyl]methyl]sulfanyl-1H-indole-3-carbaldehyde; 3-Formyl-1-methyl-2-[(3-trifluoromethylbenzyl)thio]indole; 2-[(3-Trifluoromethylbenzyl)thio]-1-methyl-1H-indole-3-carboxaldehyde; 1-Methyl-2-[(3-trifluoromethylbenzyl)thio]-1H-indole-3-carbaldehyde; CAS 338416-41-4; MFCD11846963
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-2-([3-(Trifluoromethyl)Benzyl]Sulfanyl)-1H-Indole-3-Carbaldehyde adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality management system is designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates, ensuring traceability and documentation integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening containers to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.