Description

1-(p-Fluorophenyl)-2-Hydroxy-2-Methyl-1-Propanone is a specialized organic compound featuring a fluorinated aromatic ketone structure with a tertiary alcohol group. This unique molecular architecture makes it a valuable high-purity intermediate for advanced chemical synthesis, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought by pharmaceutical R&D and fine chemical manufacturing sectors for constructing complex molecules where its fluorophenyl and hydroxy-ketone moieties are critical functional handles.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated organic compounds used in electronic displays and optoelectronic devices.
• Photoinitiator Research: Investigated for potential use in UV-curable coatings, inks, and adhesives due to its hydroxy ketone structure.
• Custom Fine Chemical Synthesis: Employed in contract research and manufacturing (CRAM) for producing tailored, high-value specialty chemicals.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry, including asymmetric synthesis and fluorination chemistry.

Basic Information

Item	Detail
Product Name	1-(p-Fluorophenyl)-2-Hydroxy-2-Methyl-1-Propanone
CAS No.	335287-91-7
Molecular Formula	C10H11FO2
Molecular Weight	182.19 g/mol
Synonyms	1-(4-Fluorophenyl)-2-hydroxy-2-methylpropan-1-one; p-Fluorobenzoyldimethylcarbinol; 2-Hydroxy-2-methyl-1-(4-fluorophenyl)-1-propanone; 4-Fluoro-α-hydroxyisobutyrophenone; α,α-Dimethyl-4-fluoromandelic Acid Ketone; 1-Propanone, 1-(4-fluorophenyl)-2-hydroxy-2-methyl-
EINECS	Contact for details

Quality Control

Our production of 1-(p-Fluorophenyl)-2-Hydroxy-2-Methyl-1-Propanone adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality system is designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) to maintain product integrity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.