Description

3-(Chlorocarbonylphenyl)Boronic Anhydride is a high-value organoboron building block characterized by its bifunctional reactivity, combining a boronic acid anhydride group with an acid chloride moiety. This compound is essential for facilitating efficient cross-coupling reactions and subsequent derivatization in a single synthetic sequence, significantly streamlining the production of complex molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing novel chemical entities, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate Synthesis: A key precursor in Suzuki-Miyaura cross-coupling reactions for the construction of biaryl and heterobiaryl scaffolds found in drug candidates.
• Advanced Material Development: Used in the synthesis of boron-containing polymers and organic electronic materials for applications in OLEDs and sensors.
• Ligand and Catalyst Preparation: Serves as a starting material for creating sophisticated boronic acid-based ligands and catalysts used in asymmetric synthesis.
• Proteolysis-Targeting Chimera (PROTAC) & Bifunctional Molecules: Enables the modular construction of linker segments in targeted protein degradation technologies.
• Chemical Biology & Bioconjugation: Utilized for labeling biomolecules or modifying surfaces due to its dual-reactive handles.
• Agrochemical Research: Employed in the discovery and synthesis of new agrochemicals with novel modes of action.

Basic Information

Item	Details
Product Name	3-(Chlorocarbonylphenyl)Boronic Anhydride
CAS No.	332154-58-2
Molecular Formula	C14H8BClO3
Molecular Weight	270.48 g/mol
Synonyms	3-Carboxybenzene boronic acid anhydride chloride; 3-(Chlorocarbonyl)benzeneboronic anhydride; 3-(Chlorocarbonyl)phenylboronic anhydride; 3-Carboxybenzene boronic acid cyclic anhydride chloride; Boronic acid, B,B'-[1,1'-[(3-chlorocarbonyl)-1,3-phenylene]bis[oxy]]bis-; [3-(Chlorocarbonyl)phenyl]boronic anhydride; 3-(Chlorocarbonyl)phenylboroxine; 3-Carboxybenzene boronic acid cyclic anhydride
EINECS	Contact for details

Quality Control

Our 3-(Chlorocarbonylphenyl)Boronic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and FTIR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive (hygroscopic) nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (THF, DCM, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.