Description

Tetrahydrofuran-2-Boronic Acid Pinacol Ester is a high-purity, heterocyclic boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing active pharmaceutical ingredients (APIs) and novel organic frameworks.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing complex heterocyclic scaffolds found in drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science Research: Serves as a monomer or building block for creating novel polymers, organic semiconductors, and liquid crystals.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes, enzyme inhibitors, and other bioactive compounds for research.
• Catalyst & Ligand Development: Used to synthesize novel bidentate or tridentate ligands for asymmetric catalysis and transition metal complexes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise introduction of a tetrahydrofuran moiety.

Basic Information

Product Name	Tetrahydrofuran-2-Boronic Acid Pinacol Ester
CAS No.	331958-88-4
Molecular Formula	C10H19BO3
Molecular Weight	198.07 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)tetrahydrofuran; Tetrahydro-2-furanboronic Acid Pinacol Ester; 2-Tetrahydrofuranylboronic Acid Pinacol Ester; THF-2-Boronic Acid Pinacol Ester; 2-(Tetrahydrofuran-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)oxolane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and manufacturing. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and GC to verify identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) documenting all relevant specifications are available upon request, supporting your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated place. This compound is easily oxidized; prolonged exposure to air or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95.0% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.