Description

2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is a high-purity, functionalized phenol derivative containing a pinacol boronate ester group, making it a versatile and valuable advanced pharmaceutical intermediate and organic synthesis building block. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality boron reagents for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing biaryl or substituted phenol motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed cross-coupling reactions with aryl halides to form new carbon-carbon bonds, enabling the construction of complex organic molecules.
• Agrochemical Synthesis: Serves as a key intermediate in the development of novel herbicides, fungicides, and insecticides that require specific phenolic and boronic ester functionalities.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis or as a precursor for functional materials.
• Material Science Research: Employed in the synthesis of organic electronic materials, polymers, and liquid crystals where precise molecular structure is paramount.
• Chemical Biology Probes: Acts as a starting material for creating tagged molecules or probes used in biochemical and cellular studies.

Basic Information

Product Name	2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol
CAS No.	331273-58-6
Molecular Formula	C13H19BO3
Molecular Weight	234.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylphenol; 2-Methyl-5-(pinacolboryl)phenol; 3-Hydroxy-4-methylphenylboronic acid pinacol ester; 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenol; Phenol, 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC analysis, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP manufacturing standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.