Description

2-Boc-Amino-3-Chloro-Pyridine-5-Boronic Acid Pinacol Ester is a high-value, multifunctional boronic ester building block extensively used in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, most notably the Suzuki-Miyaura coupling, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate in the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester functionality enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, crucial for constructing biaryl and heterobiaryl scaffolds.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific pyridine-based heterocyclic structures.
• Material Science & OLED Development: Serves as a precursor for creating advanced organic electronic materials, including ligands for catalysts and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client R&D programs.

Basic Information

Product Name	2-Boc-Amino-3-Chloro-Pyridine-5-Boronic Acid Pinacol Ester
CAS No.	330794-10-0
Molecular Formula	C₁₆H₂₄BClN₂O₄
Molecular Weight	354.64 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-chloro-2-[(tert-butoxycarbonyl)amino]pyridine; 2-[(tert-Butoxycarbonyl)amino]-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Chloro-2-((tert-butoxycarbonyl)amino)pyridine-5-boronic acid pinacol ester; 2-(Boc-amino)-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Boc-3-Chloro-2-aminopyridine-5-boronic acid pinacol ester; 2-(N-Boc-amino)-3-chloropyridine-5-boronic acid pinacol ester; 330794-10-0; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of 2-Boc-Amino-3-Chloro-Pyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency that meets the stringent requirements of pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.