Description

4-(n-Boc-Amino)Phenylboronic Acid Pinacol Ester is a high-purity, protected boronic ester derivative, serving as a critical synthetic intermediate in modern organic and medicinal chemistry. Its core value lies in providing a stable, protected amine functionality that is compatible with palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, modular construction of complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and functionalized aromatic systems.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in constructing biaryl motifs common in kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a stable boronate ester partner for coupling with aryl/heteroaryl halides to form carbon-carbon bonds under mild conditions.
• Peptide Mimetics & Conjugate Synthesis: Used to introduce protected amino-phenyl groups into peptides or other biomolecules for structure-activity relationship (SAR) studies.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides with complex aromatic backbones.
• Material Science & OLED Development: Building block for creating organic semiconductors, light-emitting materials, and other functional polymers requiring specific aromatic amine architectures.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for orthogonal deprotection, enabling complex multi-step syntheses.

Basic Information

Product Name	4-(n-Boc-Amino)Phenylboronic Acid Pinacol Ester
CAS No.	330793-01-6
Molecular Formula	C₁₇H₂₆BNO₄
Molecular Weight	319.21 g/mol
Synonyms	4-(Boc-amino)phenylboronic acid pinacol ester; 4-(tert-Butoxycarbonylamino)phenylboronic acid pinacol ester; 4-[(tert-Butoxycarbonyl)amino]benzeneboronic acid pinacol ester; 4-(N-Boc-amino)phenylboronic acid pinacol ester; 4-(Boc-NH-Ph)-Bpin; 4-Aminophenylboronic acid pinacol ester, N-Boc protected; [4-[[(1,1-Dimethylethoxy)carbonyl]amino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(n-Boc-Amino)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards required for cGMP and non-GMP pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.