Description

(E)-1,1,1-Trifluoro-4-(Phenylsulfonyl)But-3-Ene-2,2-Diol is a high-value, fluorinated organic building block characterized by its unique combination of a sulfonyl group and a gem-diol adjacent to a trifluoromethyl moiety. This compound matters for its role as a versatile synthon in advanced organic synthesis, enabling the introduction of fluorine atoms and functional handles critical for modulating the physicochemical properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination reactions and the stereoelectronic effects of the CF3 group.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring complex fluorinated architectures.

Basic Information

Product Name	(E)-1,1,1-Trifluoro-4-(Phenylsulfonyl)But-3-Ene-2,2-Diol
CAS No.	329915-01-7
Molecular Formula	C10H9F3O4S
Molecular Weight	282.24 g/mol
Synonyms	(E)-1,1,1-Trifluoro-4-(phenylsulfonyl)but-3-ene-2,2-diol; 4-(Phenylsulfonyl)-1,1,1-trifluoro-3-buten-2,2-diol; (E)-4-(Benzenesulfonyl)-1,1,1-trifluorobut-3-ene-2,2-diol; 1,1,1-Trifluoro-4-(phenylsulfonyl)-3-buten-2,2-diol; (E)-1,1,1-Trifluoro-4-(phenylsulfonyl)but-3-ene-2,2-diol; 329915-01-7; Trifluoromethyl phenylsulfonyl butenediol
EINECS	Contact for details

Quality Control

Our (E)-1,1,1-Trifluoro-4-(Phenylsulfonyl)But-3-Ene-2,2-Diol is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with client specifications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.