Description

Dichloro[(R)-(-)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2,2]-Paracyclophane][(1S,2S)-(-)-1,2-Diphenylethylenediamine]Ruthenium is a highly specialized, chiral ruthenium complex designed for asymmetric catalysis. This compound matters because it serves as a precise and efficient catalyst for enantioselective hydrogenation and other critical synthetic transformations, enabling the production of single-isomer pharmaceutical intermediates and fine chemicals. It is essential for R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors who require high stereochemical control and process reliability.

Application

• Asymmetric Hydrogenation Catalyst: Key for the enantioselective synthesis of chiral amines, amino acids, and alcohols, which are vital building blocks for active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Enables the production of high-purity, single-enantiomer compounds for drug development and manufacturing.
• Fine Chemical Production: Used in the synthesis of complex, high-value specialty chemicals where stereoselectivity is paramount.
• Agrochemical Research: Applicable in creating chiral active ingredients for herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Employed to develop scalable, efficient, and cost-effective catalytic processes for industrial manufacturing.

Basic Information

Item	Detail
Product Name	Dichloro[(R)-(-)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2,2]-Paracyclophane][(1S,2S)-(-)-1,2-Diphenylethylenediamine]Ruthenium
CAS No.	325150-57-0
Molecular Formula	C66H66Cl2N2P2Ru
Molecular Weight	1088.06 g/mol
Synonyms	Ru-Mandyphos Catalyst; Dichloro[(R)-Mandyphos][(1S,2S)-DPEN]Ruthenium; Ruthenium(II) (R)-Mandyphos (S,S)-DPEN dichloride; (R)-Mandyphos/(S,S)-DPEN-RuCl2; Asymmetric Hydrogenation Catalyst Ru-Mandyphos-DPEN; [RuCl2((R)-Mandyphos)((S,S)-DPEN)]; CAS 325150-57-0; Ruthenium complex with Mandyphos and DPEN ligands.
EINECS	Contact for details

Quality Control

Our high-value chiral catalysts are produced and handled under strict quality-controlled conditions to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques, including NMR and HPLC, to confirm identity, enantiomeric purity, and absence of critical metallic impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Ruthenium Content	9.3 - 9.7%
Chloride Content	6.4 - 6.8%
Solubility	Soluble in dichloromethane, toluene; slightly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.