Description

4,4,5,5-Tetramethyl-2-(2,4,6-Trifluorophenyl)-1,3,2-Dioxaborolane CAS NO 325143-04-2 is a high-purity, trifluorinated aryl boronic ester derivative, serving as a critical advanced synthetic intermediate in modern organic chemistry. Its primary value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise and efficient routes to fluorinated aromatic systems.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl or fluorinated aryl groups to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the introduction of fluorine atoms improves efficacy and environmental profile.
• Materials Science & OLED Development: Crucial precursor for manufacturing fluorinated organic electronic materials, including charge-transport layers and emitters in organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Chemical Research & Development: Enables the exploration of new chemical space in academic and industrial R&D labs for drug discovery and functional material design.
• Fluorinated Liquid Crystal Synthesis: Intermediate in the production of fluorinated liquid crystals for advanced display technologies.

Basic Information

Item	Details
Product Name	4,4,5,5-Tetramethyl-2-(2,4,6-Trifluorophenyl)-1,3,2-Dioxaborolane
CAS No.	325143-04-2
Molecular Formula	C14H17BF3O2
Molecular Weight	276.09 g/mol
Synonyms	2-(2,4,6-Trifluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2,4,6-Trifluorophenyl)boronic acid pinacol ester; 2,4,6-Trifluorophenylboronic acid pinacol ester; 2,4,6-Trifluorophenyl-Bpin; 4,4,5,5-Tetramethyl-2-(2,4,6-trifluorophenyl)-1,3,2-dioxaborolane; Pinacol (2,4,6-Trifluorophenyl)boronate; 2,4,6-TrifluorophenylBPin
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(2,4,6-Trifluorophenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B) and HPLC analysis, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.